MCI-DTI Biomarker Development

 
   Lead Investigator:    Leonard Wesley
   Institution      :    San Jose State University
   E-Mail           :    leonard.wesley@sjsu.edu
   Proposal ID      :    1520



   Proposal Description:
   GOAL-1:  Quantity and characterize the ability of a NODDI and personalized  track analysis of a masked hippocampus region of individuals.                     GOAL-2: Develop ML models to predict and discern control, MCI, nonMCI, and aMCI  subjects from NODDI analysis combined with RAVLT, MOCA, APOE4, vascular, and     resting state data.                                                               EXPECTED IMPACT: Improve current MCI prediction accuracy, precision, and         recall.                                                                           OBJECTIVE-1:  To test null and alternative hypothesis RE ability of selected     features to predict MCI with greater accuracy, precision, and recall.             OBJECTIVE-2: Assess prediction results using a mathematical calculus called       evidential reasoning to characterize what is and is not known about predictions  with greater fidelity than is currently possible.